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Selective IgA Deficiency and Allergy: A Fresh Look to an Old Story
| Content Provider | MDPI |
|---|---|
| Author | Cinicola, Bianca Laura Pulvirenti, Federica Capponi, Martina Bonetti, Marta Brindisi, Giulia Gori, Alessandra Castro, Giovanna De Anania, Caterina Duse, Marzia Zicari, Anna Maria |
| Copyright Year | 2022 |
| Description | Selective IgA deficiency (SIgAD) is the most common human primary immune deficiency (PID). It is classified as a humoral PID characterized by isolated deficiency of IgA (less than 7 mg/dL but normal serum IgG and IgM) in subjects greater than 4 years of age. Intrinsic defects in the maturation of B cells and a perturbation of Th cells and/or cytokine signals have been hypothesized to contribute to SIgAD pathogenesis. The genetic basis of IgA deficiency remains to be clarified. Patients with SIgAD can be either asymptomatic or symptomatic with clinical manifestations including allergy, autoimmunity and recurrent infections mainly of the respiratory and gastrointestinal tract. Studies analyzing allergy on SIgAD patients showed prevalence up to 84%, supporting in most cases the relationship between sIgAD and allergic disease. However, the prevalence of allergic disorders may be influenced by various factors. Thus, the question of whether allergy is more common in SIgAD patients compared to healthy subjects remains to be defined. Different hypotheses support an increased susceptibility to allergy in subjects with SIgAD. Recurrent infections due to loss of secretory IgA might have a role in the pathogenesis of allergy, and vice versa. Perturbation of microbiota also plays a role. The aim of this review is to examine the association between SIgAD and atopic disease and to update readers on advances over time at this important interface between allergy and SIgAD. |
| Starting Page | 129 |
| e-ISSN | 16489144 |
| DOI | 10.3390/medicina58010129 |
| Journal | Medicina |
| Issue Number | 1 |
| Volume Number | 58 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-15 |
| Access Restriction | Open |
| Subject Keyword | Medicina Allergy Sigad Immunology Infections Asthma Microbiota |
| Content Type | Text |
| Resource Type | Article |
