NDLI: Clinical Relevance of Drug Interactions with Cannabis: A Systematic Review

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Clinical Relevance of Drug Interactions with Cannabis: A Systematic Review

Content Provider	MDPI
Author	Adriana, Rodríguez Lopera, Valentina Amariles, Pedro
Copyright Year	2022
Description	Concomitant use of cannabis with other drugs may lead to cannabis–drug interactions, mainly due to the pharmacokinetic mechanism involving the family of CYP450 isoenzymes. This narrative systematic review aimed to systematize the available information regarding clinical relevance of cannabis–drug interactions. We utilized the PubMed/Medline database for this systematic review, using the terms drug interactions and cannabis, between June 2011 and June 2021. Articles with cannabis–drug interactions in humans, in English or Spanish, with full-text access were selected. Two researchers evaluated the article’s inclusion. The level of clinical relevance was determined according to the severity and probability of the interaction. Ninety-five articles were identified and twenty-six were included. Overall, 19 pairs of drug interactions with medicinal or recreational cannabis were identified in humans. According to severity and probability, 1, 2, 12, and 4 pairs of cannabis–drug interactions were classified at levels 1 (very high risk), 2 (high risk), 3 (medium risk), and 5 (without risk), respectively. Cannabis–warfarin was classified at level 1, and cannabis–buprenorphine and tacrolimus at level 2. This review provides evidence for both the low probability of the occurrence of clinically relevant drug interactions and the lack of evidence regarding cannabis–drug interactions.
Starting Page	1154
e-ISSN	20770383
DOI	10.3390/jcm11051154
Journal	Journal of clinical medicine
Issue Number	5
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-02-22
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Substance Abuse Drug Interactions Medicinal Cannabis Recreational Cannabis Clinical Relevance Severity Probability
Content Type	Text
Resource Type	Article

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