NDLI: Non-Invasive Monitoring of Inflammation in Inflammatory Bowel Disease Patients during Prolonged Exercise via Exhaled Breath Volatile Organic Compounds

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Non-Invasive Monitoring of Inflammation in Inflammatory Bowel Disease Patients during Prolonged Exercise via Exhaled Breath Volatile Organic Compounds

Content Provider	MDPI
Author	Du, šan Materić Henderson, Ben Meurs, Joris Lamers, Carlijn R. Batista, Guilherme Lopes Bertinetto, Carlo G. Bongers, Coen C. W. G. Holzinger, Rupert Harren, Frans J. M. Jansen, Jeroen J. Hopman, Maria T. E. Cristescu, Simona M.
Copyright Year	2022
Description	The aim of this study was to investigate volatile organic compounds (VOCs) in exhaled breath as possible non-invasive markers to monitor the inflammatory response in inflammatory bowel disease (IBD) patients as a result of repeated and prolonged moderate-intensity exercise. We included 18 IBD patients and 19 non-IBD individuals who each completed a 30, 40, or 50 km walking exercise over three consecutive days. Breath and blood samples were taken before the start of the exercise event and every day post-exercise to assess changes in the VOC profiles and cytokine concentrations. Proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) was used to measure exhaled breath VOCs. Multivariate analysis, particularly ANOVA-simultaneous component analysis (ASCA), was employed to extract relevant ions related to exercise and IBD. Prolonged exercise induces a similar response in breath butanoic acid and plasma cytokines for participants with or without IBD. Butanoic acid showed a significant correlation with the cytokine IL-6, indicating that butanoic acid could be a potential non-invasive marker for exercise-induced inflammation. The findings are relevant in monitoring personalized IBD management.
Starting Page	224
e-ISSN	22181989
DOI	10.3390/metabo12030224
Journal	Metabolites
Issue Number	3
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-03-03
Access Restriction	Open
Subject Keyword	Metabolites Toxicology Inflammatory Bowel Disease Exercise Breath Analysis Ptr-tof-ms Volatile Organic Compounds Butanoic Acid
Content Type	Text
Resource Type	Article

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