NDLI: Carissa macrocarpa Leaves Polar Fraction Ameliorates Doxorubicin-Induced Neurotoxicity in Rats via Downregulating the Oxidative Stress and Inflammatory Markers

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Carissa macrocarpa Leaves Polar Fraction Ameliorates Doxorubicin-Induced Neurotoxicity in Rats via Downregulating the Oxidative Stress and Inflammatory Markers

Content Provider	MDPI
Author	Orabi, Mohamed A. A. Khalil, Heba M. A. Abouelela, Mohamed E. Zaafar, Dalia Ahmed, Yasmine H. Naggar, Reham A. Alyami, Hamad S. Abdel-Sattar, El-Shaymaa Matsunami, Katsuyoshi Hamdan, Dalia I.
Copyright Year	2021
Description	Chemotherapeutic-related toxicity exacerbates the increasing death rate among cancer patients, necessitating greater efforts to find a speedy solution. An in vivo assessment of the protective effect of the C. macrocarpa leaves polar fraction of hydromethanolic extract against doxorubicin (Dox)-induced neurotoxicity was performed. Intriguingly, this fraction ameliorated Dox-induced cognitive dysfunction; reduced serum ROS and brain TNF-α levels, upregulated the brain nerve growth factor (NGF) levels, markedly reduced caspase-3 immunoexpression, and restored the histological architecture of the brain hippocampus. The in vivo study results were corroborated with a UPLC-ESI-MS/MS profiling that revealed the presence of a high percentage of the plant polyphenolics. Molecular modeling of several identified molecules in this fraction demonstrated a strong binding affinity of flavan-3-ol derivatives with TACE enzymes, in agreement with the experimental in vivo neuroprotective activity. In conclusion, the C. macrocarpa leaves polar fraction possesses neuroprotective activity that could have a promising role in ameliorating chemotherapeutic-induced side effects.
Starting Page	1305
e-ISSN	14248247
DOI	10.3390/ph14121305
Journal	Pharmaceuticals
Issue Number	12
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2021-12-14
Access Restriction	Open
Subject Keyword	Pharmaceuticals Oncology Carissa Macrocarpa Cytotoxicity Uplc-esi-ms/ms Doxorubicin Neurotoxicity Molecular Docking
Content Type	Text
Resource Type	Article

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