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Palladium-Catalyzed Dehydrogenative C-2 Alkenylation of 5-Arylimidazoles and Related Azoles with Styrenes
| Content Provider | MDPI |
|---|---|
| Author | Lessi, Marco Nania, Attilio Pittari, Melania Lodone, Laura Cuzzola, Angela Bellina, Fabio |
| Copyright Year | 2021 |
| Description | The construction of carbon–carbon bonds by direct involvement of two unactivated carbon–hydrogen bonds, without any directing group, ensures a high atom economy of the entire process. Here, we describe a simple protocol for the Pd(II)/Cu(II)-promoted intermolecular cross-dehydrogenative coupling (CDC) of 5-arylimidazoles, benzimidazoles, benzoxazole and 4,5-diphenylimidazole at their C-2 position with functionalized styrenes. This specific CDC, known as the Fujiwara–Moritani reaction or oxidative Heck coupling, also allowed the C-4 alkenylation of the imidazole nucleus when both 2 and 5 positions were occupied. |
| Starting Page | 762 |
| e-ISSN | 20734344 |
| DOI | 10.3390/catal11070762 |
| Journal | Catalysts |
| Issue Number | 7 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-23 |
| Access Restriction | Open |
| Subject Keyword | Catalysts Organic Chemistry C-h Activation Imidazoles Fujiwara–moritani Reaction Dehydrogenative Coupling Oxidative Heck Coupling Styrenes Palladium Catalysis Copper Salts |
| Content Type | Text |
| Resource Type | Article |
