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Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study
| Content Provider | MDPI |
|---|---|
| Author | Akagi, Tadamichi Okamoto, Yoko Kameda, Takanori Suda, Kenji Nakanishi, Hideo Miyake, Masahiro Ikeda, Hanako Ohashi Yamada, Tatsuya Kadomoto, Shin Uji, Akihito Tsujikawa, Akitaka |
| Copyright Year | 2020 |
| Description | Background: To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. Methods: This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was introduced into the right eyes of the participants. The superficial (conjunctival) and deep (intrascleral) vasculatures of the corneal limbus using anterior-segment optical coherence tomography angiography (OCTA) and IOP were examined in both eyes at baseline and 15 min and 2 h after instillation. Results: In the ripasudil group, the vessel density (VD) (median) at baseline (deep, 13.1%; superficial, 28.5%) significantly increased in both layers at 15 min (deep, 19.9%; superficial, 37.3%) and the deep layer at 2 h (deep, 14.8%; superficial, 31.6%). In the bimatoprost group, the superficial VD significantly changed over time, but the deep VD did not. The greater effect of ripasudil on IOP reduction was significantly associated with a lower baseline VD in the deep layer (at 15 min, p = 0.004; at 2 h, p = 0.018). Conclusions: Differences in the timing, depth, and extent of the effects on vasculature after instillations, could be detected using OCTA. The IOP-lowering effects of ripasudil might be associated with the deep vasculature. |
| Starting Page | 4016 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm9124016 |
| Journal | Journal of clinical medicine |
| Issue Number | 12 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-12-11 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Ophthalmology Anterior Segment Optical Coherence Tomography Angiography Anti-glaucoma Eyedrop Aqueous Humor Outflow Pathway Intraocular Pressure Reduction |
| Content Type | Text |
| Resource Type | Article |
