NDLI: Fermented Rice Germ Extract Ameliorates Abnormal Glucose Metabolism via Antioxidant Activity in Type 2 Diabetes Mellitus Mice

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Fermented Rice Germ Extract Ameliorates Abnormal Glucose Metabolism via Antioxidant Activity in Type 2 Diabetes Mellitus Mice

Content Provider	MDPI
Author	Hyun, Ye Kim, Ju Jung, Sung Kim, Ji
Copyright Year	2021
Description	Rice germ is an abundant source of ferulic acid, which is known for its anti-oxidant activity. This study aimed to evaluate the regulatory effects of fermented rice germ extracts on hepatic glucose metabolism in C57BL/KsJ-db/db mice. Rice germ was fermented with Lactobacillus plantarum and extracted with 30% ethanol (RG_30E) or 50% ethanol (RG_50E). Mice were fed modified AIN-93 diets containing fermented rice germ extracts and ferulic acid for 8 weeks. RG_50E significantly reduced food intake as well as liver weight and RG_30E and RG_50E improved glucose homeostasis, as indicated by fasting blood glucose levels and glucose tolerance. Hepatic triglyceride and total cholesterol levels were significantly decreased in db/db mice fed RG_30E and RG_50E. The antioxidant capacity of RG_30E and RG_50E was confirmed by a decrease in malondialdehyde levels and an increase in hepatic superoxide dismutase activity. The expression of genes related to glycolysis and gluconeogenesis was significantly regulated by RG_30E and RG_50E. These results suggest that fermented rice germ extracts have the potential to regulate hypoglycemia and hepatic glucose metabolism in type 2 diabetes db/db mice.
Starting Page	3091
e-ISSN	20763417
DOI	10.3390/app11073091
Journal	Applied Sciences
Issue Number	7
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2021-03-31
Access Restriction	Open
Subject Keyword	Applied Sciences Agriculture and Animal Production Integrative and Complementary Medicine Rice Germ Ferulic Acid Type 2 Diabetes Mellitus Hypoglycemia Effect Hepatic Glucose Metabolism
Content Type	Text
Resource Type	Article

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