NDLI: Embedding a Sensitive Liquid-Core Waveguide UV Detector into an HPLC-UV System for Simultaneous Quantification of Differently Dosed Active Ingredients during Drug Release

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Embedding a Sensitive Liquid-Core Waveguide UV Detector into an HPLC-UV System for Simultaneous Quantification of Differently Dosed Active Ingredients during Drug Release

Content Provider	MDPI
Author	Chamberlain, Rebecca Windolf, Hellen Burckhardt, Bjoern B. Breitkreutz, Jörg Fischer, Björn
Copyright Year	2022
Description	Individual dosing of pharmaceutics and personalized medicine have become important with regard to therapeutic safety. Dose adjustments, biorelevant drug release and combination of multiple active substances in one dosage form for the reduction in polymedication are essential aspects that increase the safety and acceptance of the patient’s pharmacotherapy. Therefore, not only innovative drug products but also new analytical methods are needed during the drug development phase and for quality control that can simultaneously determine different active ingredients and cover wide concentration ranges. We investigated a liquid-core waveguide UV absorbance flow cell detector coupled to an existing HPLC-UV system. A Teflon AF 2400 capillary tubing of 20 cm length was connected in series to the HPLC flow line and enabled a lower limit of quantification of 1 ng/mL pramipexole (increase in sensitivity by 20 compared to common 0.9 cm flow cells). This allowed the low-concentration of pramipexole and the higher concentrations of levodopa and benserazide occurring during drug release to be determined in a single chromatographic run within 22.5 min.
Starting Page	639
e-ISSN	19994923
DOI	10.3390/pharmaceutics14030639
Journal	Pharmaceutics
Issue Number	3
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-03-14
Access Restriction	Open
Subject Keyword	Pharmaceutics Anesthesiology Liquid-core Waveguide Hot Melt Extrusion Low-dosed Dosage Forms Analytics of Extruded Filaments Fused Filament 3d Printing Oral Dosage Form Personalized Medicine
Content Type	Text
Resource Type	Article

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