NDLI: Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro

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Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro

Content Provider	MDPI
Author	Anja, Kreiß Andreas, Schäffler Schmid, Andreas Gehl, Jonas Thomalla, Miriam Hochberg, Alexandra Patz, Marissa Karrasch, Thomas
Copyright Year	2020
Description	The adipokine CTRP-3 (C1q/TNF-related protein-3) exerts anti-inflammatory and anti-diabetic effects. Its regulation in obesity and during weight loss is unknown. Serum and adipose tissue (AT) samples were obtained from patients (n = 179) undergoing bariatric surgery (BS). Moreover, patients (n = 131) participating in a low-calorie diet (LCD) program were studied. CTRP 3 levels were quantified by ELISA and mRNA expression was analyzed in AT and in 3T3-L1 adipocytes treated with bile acids and incretins. There was a persistent downregulation of CTRP-3 serum levels during weight loss. CTRP-3 expression was higher in subcutaneous than in visceral AT and serum levels of CTRP-3 were positively related to AT expression levels. A rapid decrease of circulating CTRP-3 was observed immediately upon BS, suggesting weight loss-independent regulatory mechanisms. Adipocytes CTRP-3 expression was inhibited by primary bile acid species and GLP 1. Adipocyte-specific CTRP-3 deficiency increased bile acid receptor expression. Circulating CTRP-3 levels are downregulated during weight loss, with a considerable decline occurring immediately upon BS. Mechanisms dependent and independent of weight loss cause the post-surgical decline of CTRP-3. The data strongly argue for regulatory interrelations of CTRP-3 with bile acids and incretin system.
Starting Page	8168
e-ISSN	14220067
DOI	10.3390/ijms21218168
Journal	International Journal of Molecular Sciences
Issue Number	21
Volume Number	21
Language	English
Publisher	MDPI
Publisher Date	2020-10-31
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Endocrinology and Metabolism C1q/tnf-related Protein-3 Obesity Bariatric Surgery Low Calorie Diet Bile Acids Incretins
Content Type	Text
Resource Type	Article

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