NDLI: Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1

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Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1

Content Provider	MDPI
Author	Ngamsri, Kristian-Christos Fuhr, Anika Schindler, Katharina Simelitidis, Mariana Hagen, Michelle Zhang, Yi Gamper-Tsigaras, Jutta Konrad, Franziska M.
Copyright Year	2022
Description	Acute respiratory distress syndrome is a life-threatening disease associated with high mortality. The adenosine receptor A2B (Adora2b) provides anti-inflammatory effects, which are also associated with the intracellular enzyme heme oxygenase-1 (HO-1). Our study determined the mechanism of sevoflurane’s protective properties and investigated the link between sevoflurane and the impact of a functional Adora2b via HO-1 modulation during lipopolysaccharide (LPS)-induced lung injury. We examined the LPS-induced infiltration of polymorphonuclear neutrophils (PMNs) into the lung tissue and protein extravasation in wild-type and Adora2b−/− animals. We generated chimeric animals, to identify the impact of sevoflurane on Adora2b of hematopoietic and non-hematopoietic cells. Sevoflurane decreased the LPS-induced PMN-infiltration and diminished the edema formation in wild-type mice. Reduced PMN counts after sevoflurane treatment were detected only in chimeric mice, which expressed Adora2b exclusively on leukocytes. The Adora2b on hematopoietic and non-hematopoietic cells was required to improve the permeability after sevoflurane inhalation. Further, sevoflurane increased the protective effects of HO-1 modulation on PMN migration and microvascular permeability. These protective effects were abrogated by specific HO-1 inhibition. In conclusion, our data revealed new insights into the protective mechanisms of sevoflurane application during acute pulmonary inflammation and the link between sevoflurane and Adora2b, and HO-1 signaling, respectively.
Starting Page	1094
e-ISSN	20734409
DOI	10.3390/cells11071094
Journal	Cells
Issue Number	7
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-03-24
Access Restriction	Open
Subject Keyword	Cells Anesthesiology Acute Lung Injury Neutrophils Anesthetic Agent Adora2b Ho-1
Content Type	Text
Resource Type	Article

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