Loading...
Please wait, while we are loading the content...
Similar Documents
Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads
| Content Provider | MDPI |
|---|---|
| Author | Kang, Habyeong Kim, Hee-Sun Yoon, Yeong Sook Lee, Jeongsun Kho, Younglim Lee, Jisun Chang, Hye Jin Cho, Yoon Hee Kim, Young Ah |
| Copyright Year | 2021 |
| Description | Exposure to perfluoroalkyl substances (PFASs) is of public concern due to their persistent exposure and adverse health effects. Placental transfer of PFASs is an important excretion pathway of these chemicals in pregnant women and exposure route in fetuses. We measured PFAS concentrations in maternal, paternal, and umbilical cord serum collected from 62 pregnant Korean women and matched biological fathers of the fetuses. Placental transfer rates (cord to maternal serum ratio) of PFASs were also calculated. Demographics and pregnancy-related factors determining the placental transfer rates were identified using linear regression models. Maternal, paternal, and cord serum showed different PFASs compositions. Among the PFASs, perfluorooctane sulfonate (PFOS) showed the highest concentrations in maternal and paternal serum, while perfluorooctanoic acid (PFOA) showed the highest concentration in cord serum. There was a higher proportion of perfluoroalkyl carboxylic acids (PFCAs) with 9–12 carbon chains than those with 13–14 carbon chains in maternal and paternal serum, but this proportion was in the opposite direction in cord serum. PFOA and perfluorohexane sulfonate (PFHxS) had higher placental transfer rates (means of 0.32 and 0.36, respectively) than PFOS (mean of 0.12), which is in line with the results of previous studies. Gestational age and birth weight were positively associated with placental transfer rate of PFOA, PFHxS, and PFOS, while pre-pregnant BMI and weight were inversely associated with PFOS. This study showed that placental transfer of PFASs differs by compounds and is associated with pregnancy-related factors. Further studies on novel PFASs are warranted for Korean pregnant women. |
| Starting Page | 168 |
| e-ISSN | 23056304 |
| DOI | 10.3390/toxics9070168 |
| Journal | Toxics |
| Issue Number | 7 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-14 |
| Access Restriction | Open |
| Subject Keyword | Toxics Environmental Engineering Perfluoroalkyl Acids Cord Blood Placenta Pregnancy Prenatal Exposure |
| Content Type | Text |
| Resource Type | Article |
