NDLI: Dipterocarpus tuberculatus Roxb. Ethanol Extract Has Anti-Inflammatory and Hepatoprotective Effects In Vitro and In Vivo by Targeting the IRAK1/AP-1 Pathway

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Dipterocarpus tuberculatus Roxb. Ethanol Extract Has Anti-Inflammatory and Hepatoprotective Effects In Vitro and In Vivo by Targeting the IRAK1/AP-1 Pathway

Content Provider	MDPI
Author	Kim, Haeyeop Yang, Woo Htwe, Khin Lee, Mi-Nam Kim, Young-Dong Yoon, Ki Lee, Byoung-Hee Lee, Sarah Cho, Jae
Copyright Year	2021
Description	Dipterocarpus tuberculatus Roxb. has been used traditionally as a remedy for many diseases, especially inflammation. Therefore, we analyzed and explored the mechanism of the anti-inflammatory effect of a Dipterocarpus tuberculatus Roxb. ethanol extract (Dt-EE). Dt-EE clearly and dose-dependently inhibited the expression of pro-inflammatory cytokines such as IL-6, TNF-α, and IL-1β in lipopolysaccharide (LPS)-treated RAW264.7 cells. Also, Dt-EE suppressed the activation of the MyD88/TRIF-mediated AP-1 pathway and the AP-1 pathway related proteins JNK2, MKK4/7, and TAK1, which occurred as a result of inhibiting the kinase activity of IRAK1 and IRAK4, the most upstream factors of the AP-1 pathway. Finally, Dt-EE displayed hepatoprotective activity in a mouse model of hepatitis induced with LPS/D-galactosamine (D-GalN) through decreasing the serum levels of alanine aminotransferase and suppressing the activation of JNK and IRAK1. Therefore, our results strongly suggest that Dt-EE could be a candidate anti-inflammatory herbal medicine with IRAK1/AP-1 inhibitory and hepatoprotective properties.
Starting Page	2529
e-ISSN	14203049
DOI	10.3390/molecules26092529
Journal	Molecules
Issue Number	9
Volume Number	26
Language	English
Publisher	MDPI
Publisher Date	2021-04-26
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Dipterocarpus Tuberculatus Roxb. Anti-inflammatory Effects Tumor Necrosis Factor-α Interleukin-1 Receptor-associated Kinase Activator Protein-1 Pathway Hepatitis Model
Content Type	Text
Resource Type	Article

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