NDLI: Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review

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Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review

Content Provider	MDPI
Author	Tezuka, Yuta Yamazaki, Yuto Nakamura, Yasuhiro Sasano, Hironobu Satoh, Fumitoshi
Copyright Year	2021
Description	For the last seven decades, primary aldosteronism (PA) has been gradually recognized as a leading cause of secondary hypertension harboring increased risks of cardiovascular incidents compared to essential hypertension. Clinically, PA consists of two major subtypes, surgically curable and uncurable phenotypes, determined as unilateral or bilateral PA by adrenal venous sampling. In order to further optimize the treatment, surgery or medications, diagnostic procedures from screening to subtype differentiation is indispensable, while in the general clinical practice, the work-up rate is extremely low even in the patients with refractory hypertension because of the time-consuming and labor-intensive nature of the procedures. Therefore, a novel tool to simplify the diagnostic flow has been recently in enormous demand. In this review, we focus on recent progress in the following clinically important topics of PA: prevalence of PA and its subtypes, newly revealed histopathological classification of aldosterone-producing lesions, novel diagnostic biomarkers and prediction scores. More effective strategy to diagnose PA based on better understanding of its epidemiology and pathology should lead to early detection of PA and could decrease the cardiovascular and renal complications of the patients.
Starting Page	310
e-ISSN	22279059
DOI	10.3390/biomedicines9030310
Journal	Biomedicines
Issue Number	3
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2021-03-17
Access Restriction	Open
Subject Keyword	Biomedicines Endocrinology and Metabolism Peripheral Vascular Disease Primary Aldosteronism Aldosterone-producing Adenoma Bilateral Hyperaldosteronism Histoaldo Consensus Steroid Profiling Hypertension
Content Type	Text
Resource Type	Article

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