NDLI: Extracellular Vesicles: Emerging Modulators of Cancer Drug Resistance

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Extracellular Vesicles: Emerging Modulators of Cancer Drug Resistance

Content Provider	MDPI
Author	Fontana, Fabrizio Carollo, Emanuela Melling, Genevieve Carter, David
Copyright Year	2021
Description	Extracellular vesicles (EVs) have recently emerged as crucial modulators of cancer drug resistance. Indeed, it has been shown that they can directly sequester anti-tumor drugs, decreasing their effective concentration at target sites. Moreover, they facilitate the horizontal transfer of specific bioactive cargoes able to regulate proliferative, apoptotic, and stemness programs in recipient cells, potentially conferring a resistant phenotype to drug-sensitive cancer cells. Finally, EVs can mediate the communication between the tumor and both stromal and immune cells within the microenvironment, promoting treatment escape. In this context, clarifying the EV-driven resistance mechanisms might improve not only tumor diagnosis and prognosis but also therapeutic outcomes. Detailed cellular and molecular events occurring during the development of EV-mediated cancer drug resistance are described in this review article.
Starting Page	749
e-ISSN	20726694
DOI	10.3390/cancers13040749
Journal	Cancers
Issue Number	4
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-02-11
Access Restriction	Open
Subject Keyword	Cancers Cell Tissue Engineering Extracellular Vesicles Cancer Drug Resistance Chemotherapy Mdr Transporters Mirnas Tumor Microenvironment Cancer Stem Cells
Content Type	Text
Resource Type	Article

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