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The Intersection of Purine and Mitochondrial Metabolism in Cancer
| Content Provider | MDPI |
|---|---|
| Author | Vitto, Humberto De Arachchige, Danushka B. Richardson, Brian C. French, Jarrod B. |
| Copyright Year | 2021 |
| Description | Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment. |
| Starting Page | 2603 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells10102603 |
| Journal | Cells |
| Issue Number | 10 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-30 |
| Access Restriction | Open |
| Subject Keyword | Cells Oncology Purines Mitochondrial Metabolism Amino Acids Metabolic Reprogramming Cancers |
| Content Type | Text |
| Resource Type | Article |
