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tRNA-Derived Small RNAs: Novel Epigenetic Regulators
| Content Provider | MDPI |
|---|---|
| Author | Park, Joonhyeong Ahn, Se Hee Shin, Myung Geun Kim, Hak Kyun Chang, Suhwan |
| Copyright Year | 2020 |
| Description | An epigenetic change is a heritable genetic alteration that does not involve any nucleotide changes. While the methylation of specific DNA regions such as CpG islands or histone modifications, including acetylation or methylation, have been investigated in detail, the role of small RNAs in epigenetic regulation is largely unknown. Among the many types of small RNAs, tRNA-derived small RNAs (tsRNAs) represent a class of noncoding small RNAs with multiple roles in diverse physiological processes, including neovascularization, sperm maturation, immune modulation, and stress response. Regarding these roles, several pioneering studies have revealed that dysregulated tsRNAs are associated with human diseases, such as systemic lupus, neurological disorder, metabolic disorder, and cancer. Moreover, recent findings suggest that tsRNAs regulate the expression of critical genes linked with these diseases by a variety of mechanisms, including epigenetic regulation. In this review, we will describe different classes of tsRNAs based on their biogenesis and will focus on their role in epigenetic regulation. |
| Starting Page | 2773 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers12102773 |
| Journal | Cancers |
| Issue Number | 10 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-09-27 |
| Access Restriction | Open |
| Subject Keyword | Cancers Physiology Transfer Rna Trna Fragment Trna-derived Small Rna Tsrna Trf Tirna Epigenetics Cancer |
| Content Type | Text |
| Resource Type | Article |
