NDLI: Formulation of Tioconazole and Melaleuca alternifolia Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment

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Formulation of Tioconazole and Melaleuca alternifolia Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment

Content Provider	MDPI
Author	Barbara, Vörös-Horváth Andrea, Böszörményi Tam, ás Kőszegi Szil, árd Pál Aleksandar, Széchenyi Das, Sourav Salem, Ala’ Nagy, Sándor
Copyright Year	2020
Description	Onychomycosis is a disease that affects many adults, whose treatment includes both oral and topical therapies with low cure rates. The topical therapy is less effective but causes fewer side effects. This is why the development of an effective, easy to apply formulation for topical treatment is of high importance. We have used a nanotechnological approach to formulate Pickering emulsions (PEs) with well-defined properties to achieve site-specific delivery for antifungal drug combination of tioconazole and Melaleuca alternifolia essential oil. Silica nanoparticles with tailored size and partially hydrophobic surface have been synthesized and used for the stabilization of PEs. In vitro diffusion studies have been performed to evaluate the drug delivery properties of PEs. Ethanolic solution (ES) and conventional emulsions (CE) have been used as reference drug formulations. The examination of the antifungal effect of PEs has been performed on Candida albicans and Trichophyton rubrum as main pathogens. In vitro microbiological experimental results suggest that PEs are better candidates for onychomycosis topical treatment than CE or ES of the examined drugs. The used drugs have shown a significant synergistic effect, and the combination with an effective drug delivery system can result in a promising drug form for the topical treatment of onychomycosis.
Starting Page	5544
e-ISSN	14203049
DOI	10.3390/molecules25235544
Journal	Molecules
Issue Number	23
Volume Number	25
Language	English
Publisher	MDPI
Publisher Date	2020-11-26
Access Restriction	Open
Subject Keyword	Molecules Mycology Pickering Emulsions Onychomycosis Topical Treatment Tioconazole Tea Tree Essential Oil Antifungal Activity
Content Type	Text
Resource Type	Article

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