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Point-of-Care Detection of Salivary Nitrite Based on the Surface Plasmon-Assisted Catalytic Coupling Reaction of Aromatic Amines
| Content Provider | MDPI |
|---|---|
| Author | Zhao, Chen Shi, Ruyi Wu, Jiale Luo, Xuan Liu, Xiangjiang |
| Copyright Year | 2021 |
| Description | Rapid quantification of nitrite (NO_{2}$^{−}$) in food, drink and body fluids is of significant importance for both food safety and point-of-care (POA) applications. However, conventional nitrite analytical methods are complicated, constrained to sample content, and time-consuming. Inspired by a nitrite-triggered surface plasmon-assisted catalysis (SPAC) reaction, a rapid point-of-care detection salivary nitrate was developed in this work. NO_{2}$^{−}$ ions can trigger the rapid conversion of p-aminothiophenol (PATP) to p,p′-dimercaptozaobenzene (DMAB) on gold nanoparticles (GNPs) under light illumination, and the emerged new bands at ca. 1140, 1390, 1432 $cm^{−1}$ originating from DMAB can be used to the quantification of nitrite. Meanwhile, to make the method entirely suitable for on-site fast screen or point-of-care application, the technique is needed to be further optimized. The calibration graph for nitrates was linear in the range of 1–100 µM with a correlation coefficient of 0.9579. The limit of detection was 1 µM. The facile method could lead to a further understanding of the progression and treatment of periodontitis and to guide professionals in planning on-site campaigns to effectively control periodontal diseases. |
| Starting Page | 223 |
| e-ISSN | 20796374 |
| DOI | 10.3390/bios11070223 |
| Journal | Biosensors |
| Issue Number | 7 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-05 |
| Access Restriction | Open |
| Subject Keyword | Biosensors Analytical Chemistry Spectroscopy Surface Plasmon-assisted Catalysis Surface-enhanced Raman Scattering Nitrite Saliva |
| Content Type | Text |
| Resource Type | Article |
