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Foxn1 Control of Skin Function
| Content Provider | MDPI |
|---|---|
| Author | Gawronska-Kozak, Barbara |
| Copyright Year | 2020 |
| Description | The forkhead box N1 (Foxn1) transcription factor regulates biological processes of the thymus and skin. Loss-of-function mutations in Foxn1 cause the nude phenotype in humans, mice, and rats, which is characterized by hairless skin and a lack of thymus. This review focuses on the role of Foxn1 in skin biology, including epidermal, dermal, and dermal white adipose tissue (dWAT) skin components. In particular, the role of Foxn1 in the scar-forming skin wound healing process is discussed, underscoring that Foxn1 inactivity in nude mice is permissive for scar-less cutaneous wound resolution. |
| Starting Page | 5685 |
| e-ISSN | 20763417 |
| DOI | 10.3390/app10165685 |
| Journal | Applied Sciences |
| Issue Number | 16 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-08-16 |
| Access Restriction | Open |
| Subject Keyword | Applied Sciences Dermatology Foxn1 Skin Wound Healing Regeneration |
| Content Type | Text |
| Resource Type | Article |