NDLI: Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma

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Remodeling of the Lamina Cribrosa: Mechanisms and Potential Therapeutic Approaches for Glaucoma

Content Provider	MDPI
Author	Strickland, Ryan G. Garner, Mary Anne Gross, Alecia K. Girkin, Christopher A.
Copyright Year	2022
Description	Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world. The chronic disease is characterized by optic nerve degeneration and vision field loss. The reduction of intraocular pressure remains the only proven glaucoma treatment, but it does not prevent further neurodegeneration. There are three major classes of cells in the human optic nerve head (ONH): lamina cribrosa (LC) cells, glial cells, and scleral fibroblasts. These cells provide support for the LC which is essential to maintain healthy retinal ganglion cell (RGC) axons. All these cells demonstrate responses to glaucomatous conditions through extracellular matrix remodeling. Therefore, investigations into alternative therapies that alter the characteristic remodeling response of the ONH to enhance the survival of RGC axons are prevalent. Understanding major remodeling pathways in the ONH may be key to developing targeted therapies that reduce deleterious remodeling.
Starting Page	8068
e-ISSN	14220067
DOI	10.3390/ijms23158068
Journal	International Journal of Molecular Sciences
Issue Number	15
Volume Number	23
Language	English
Publisher	MDPI
Publisher Date	2022-07-22
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Glaucoma Optic Nerve Head Lamina Cribrosa Lamina Cribrosa Cells Scleral Fibroblasts Glial Cells Intraocular Pressure
Content Type	Text
Resource Type	Article

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