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Recommended Tests for the Self-Disproportionation of Enantiomers (SDE) to Ensure Accurate Reporting of the Stereochemical Outcome of Enantioselective Reactions
| Content Provider | MDPI |
|---|---|
| Author | Han, Jianlin Wzorek, Alicja Klika, Karel Soloshonok, Vadim |
| Copyright Year | 2021 |
| Description | The purpose of this review is to highlight the necessity of conducting tests to gauge the magnitude of the self-disproportionation of enantiomers (SDE) phenomenon to ensure the veracity of reported enantiomeric excess (ee) values for scalemic samples obtained from enantioselective reactions, natural products isolation, etc. The SDE always occurs to some degree whenever any scalemic sample is subjected to physicochemical processes concomitant with the fractionation of the sample, thus leading to erroneous reporting of the true ee of the sample if due care is not taken to either preclude the effects of the SDE by measurement of the ee prior to the application of physicochemical processes, suppressing the SDE, or evaluating all obtained fractions of the sample. Or even avoiding fractionation altogether if possible. There is a clear necessity to conduct tests to assess the magnitude of the SDE for the processes applied to samples and the updated and improved recommendations described herein cover chromatography and processes involving gas-phase transformations such as evaporation or sublimation. |
| Starting Page | 2757 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26092757 |
| Journal | Molecules |
| Issue Number | 9 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-05-07 |
| Access Restriction | Open |
| Subject Keyword | Molecules Analytical Chemistry Self-disproportionation of Enantiomers (sde) Enantiomeric Analysis Molecular Association Molecular Chirality Enantiomeric Excess |
| Content Type | Text |
| Resource Type | Article |
