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Long-Term Survival after Linac-Based Stereotactic Radiosurgery and Radiotherapy with a Micro-Multileaf Collimator for Brain Metastasis
| Content Provider | MDPI |
|---|---|
| Author | Matsuda, Ryosuke Hasegawa, Masatoshi Tamamoto, Tetsuro Inooka, Nobuyoshi Nikimoto, Mei Ochi, Tomoko Miyasaka, Toshiteru Hontsu, Shigeto Yamaki, Kaori Miura, Sachiko Morimoto, Takayuki Mitsui, Takaaki Furuta, Takanori Yokoyama, Shohei Kotsugi, Masashi Yamada, Shuichi Nakagawa, Ichiro Park, Young-Soo Nakase, Hiroyuki |
| Copyright Year | 2022 |
| Description | Background: this study aimed to evaluate the prognostic factors associated with long-term survival after linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator for brain metastasis (BM). Methods: This single-center retrospective study included 226 consecutive patients with BM who were treated with linac-based SRS or fSRT with a micro-multileaf collimator between January 2011 and December 2018. Long-term survival (LTS) was defined as survival for more than 2 years after SRS/fSRT. Results: The tumors originated from the lung (n = 189, 83.6%), breast (n = 11, 4.9%), colon (n = 9, 4.0%), stomach (n = 4, 1.8%), kidney (n = 3, 1.3%), esophagus (n = 3, 1.3%), and other regions (n = 7, 3.1%). The median pretreatment Karnofsky performance scale (KPS) score was 90 (range: 40–100). The median follow-up time was 13 (range: 0–120) months. Out of the 226 patients, 72 (31.8%) were categorized in the LTS group. The median survival time was 43 months and 13 months in the LTS group and in the entire cohort, respectively. The 3-year, 4-year, and 5-year survival rate in the LTS group was 59.1%, 49.6%, and 40.7%, respectively. Multivariate regression logistic analysis showed that female sex, a pre-treatment KPS score ≥ 80, and the absence of extracranial metastasis were associated with long-term survival. Conclusions: female sex, a favorable pre-treatment KPS score, and the absence of extracranial metastasis were associated with long-term survival in the current cohort of patients with BM. |
| Ending Page | 6076 |
| Page Count | 9 |
| Starting Page | 6068 |
| e-ISSN | 17187729 |
| DOI | 10.3390/curroncol29090477 |
| Journal | Current Oncology |
| Issue Number | 9 |
| Volume Number | 29 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-24 |
| Access Restriction | Open |
| Subject Keyword | Current Oncology Oncology Linac with a Micro-multileaf Collimator Brain Metastasis Long-term Survivors Stereotactic Radiosurgery Stereotactic Radiotherapy |
| Content Type | Text |
| Resource Type | Article |
