NDLI: Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

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Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

Content Provider	MDPI
Author	Liew, Hui Shan Mai, Chun-Wai Zulkefeli, Mohd Madheswaran, Thiagarajan Kiew, Lik Voon Delsuc, Nicolas Low, May Lee
Copyright Year	2020
Description	Photodynamic therapy (PDT) is emerging as a significant complementary or alternative approach for cancer treatment. PDT drugs act as photosensitisers, which upon using appropriate wavelength light and in the presence of molecular oxygen, can lead to cell death. Herein, we reviewed the general characteristics of the different generation of photosensitisers. We also outlined the emergence of rhenium (Re) and more specifically, Re(I) tricarbonyl complexes as a new generation of metal-based photosensitisers for photodynamic therapy that are of great interest in multidisciplinary research. The photophysical properties and structures of Re(I) complexes discussed in this review are summarised to determine basic features and similarities among the structures that are important for their phototoxic activity and future investigations. We further examined the in vitro and in vivo efficacies of the Re(I) complexes that have been synthesised for anticancer purposes. We also discussed Re(I) complexes in conjunction with the advancement of two-photon PDT, drug combination study, nanomedicine, and photothermal therapy to overcome the limitation of such complexes, which generally absorb short wavelengths.
Starting Page	4176
e-ISSN	14203049
DOI	10.3390/molecules25184176
Journal	Molecules
Issue Number	18
Volume Number	25
Language	English
Publisher	MDPI
Publisher Date	2020-09-12
Access Restriction	Open
Subject Keyword	Molecules Inorganic Chemistry Cancer Medicinal Inorganic Chemistry Metals in Medicine Photodynamic Therapy Photosensitisers Rhenium(i) Tricarbonyl Complexes
Content Type	Text
Resource Type	Article

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