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Ex-Vivo Pharmacological Defatting of the Liver: A Review
| Content Provider | MDPI |
|---|---|
| Author | Goumard, Claire Turco, Célia Sakka, Mehdi Aoudjehane, Lynda Lesnik, Philippe Savier, Eric Conti, Filomena Scatton, Olivier |
| Copyright Year | 2021 |
| Description | The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model. |
| Starting Page | 1253 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm10061253 |
| Journal | Journal of clinical medicine |
| Issue Number | 6 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-18 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Transplantation Normothermic Machine Perfusion Ex-vivo Perfusion Liver Perfusion Steatosis Defatting Liver Transplantation |
| Content Type | Text |
| Resource Type | Article |
