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Four New Chromones from the Endophytic Fungus Phomopsis asparagi DHS-48 Isolated from the Chinese Mangrove Plant Rhizophora mangle
| Content Provider | MDPI |
|---|---|
| Author | Wei, Chengwen Sun, Chunxiao Feng, Zhao Zhang, Xuexia Xu, Jing |
| Copyright Year | 2021 |
| Description | Four new chromones, phomochromenones D–G (1–4), along with four known analogues, diaporchromone A (5), diaporchromanone C (6), diaporchromanone D (7), and phomochromenone C (8), were isolated from the culture of Phomopsis asparagi DHS-48 from Chinese mangrove Rhizophora mangle. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. The absolute configurations of 1 and 4 were assigned on the basis of experimental and calculated electronic circular dichroism (ECD) data, and those of enantiomers 2 and 3 were determined by a modified Mosher’s method and basic hydrolysis. To the best of our knowledge, phomochromenones D–F (1–4) possessing a 3-substituted-chroman-4-one skeleton are rarely found in natural sources. Diaporchromone A (5) showed moderate to weak immunosuppressive activity against T and/or B lymphocyte cells with $IC_{50}$ of 34 μM and 117 μM. |
| Starting Page | 348 |
| e-ISSN | 16603397 |
| DOI | 10.3390/md19060348 |
| Journal | Marine drugs |
| Issue Number | 6 |
| Volume Number | 19 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-19 |
| Access Restriction | Open |
| Subject Keyword | Marine drugs Marine Drugs Paper and Wood Mangrove Endophytic Fungi Phomopsis Sp. Chromenones Immunosuppressive Activity |
| Content Type | Text |
| Resource Type | Article |
