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The Aminometylation of 4-(Alkylthio)-6-amino-2-oxo(thioxo)-1,2-dihydropyridine-3,5-dicarbonitriles
| Content Provider | MDPI |
|---|---|
| Author | Khrapova, Ekaterina A. Ryzhkova, Natalya A. Dotsenko, Victor V. Aksenov, Nicolai A. |
| Copyright Year | 2020 |
| Description | Easily available 2-(bis(alkylthio)methylene)malononitriles react with cyanoacetamide or cyanothioacetamide to give 4-(alkylthio)-6-amino-2-oxo(thioxo)-1,2-dihydropyridine-3,5-dicarbonitriles. Upon treatment with primary amines and/or HCHO, the compounds undergo heterocyclization to afford new pyrido[1,2-a][1,3,5]triazines or ring-condensed 1,3,5,7-tetrazocine derivatives. |
| Starting Page | 30 |
| e-ISSN | 26734583 |
| DOI | 10.3390/ecsoc-24-08401 |
| Journal | Chemistry Proceedings |
| Issue Number | 1 |
| Volume Number | 3 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-11-14 |
| Access Restriction | Open |
| Subject Keyword | Chemistry Proceedings Organic Chemistry 6-aminopyridin-2-ones 2-thioxopyridines Mannich Reaction Aminomethylation Heterocyclization 1,3,5-triazines Tetrazocines |
| Content Type | Text |