NDLI: Composite Fiber Spun Mat Synthesis and In Vitro Biocompatibility for Guide Tissue Engineering

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Composite Fiber Spun Mat Synthesis and In Vitro Biocompatibility for Guide Tissue Engineering

Content Provider	MDPI
Author	Manuel, García-Hipólito Osorio-Arciniega, Rodrigo Alvarez-Fregoso, Octavio Alvarez-Perez, Marco Antonio
Copyright Year	2021
Description	Composite scaffolds are commonly used strategies and materials employed to achieve similar analogs of bone tissue. This study aims to fabricate 10% wt polylactic acid (PLA) composite fiber scaffolds by the air-jet spinning technique (AJS) doped with 0.5 or 0.1 g of zirconium oxide nanoparticles $(ZrO_{2}$) for guide bone tissue engineering. $ZrO_{2}$ nanoparticles were obtained by the hydrothermal method and characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). SEM and fourier-transform infrared spectroscopy (FTIR) analyzed the synthesized $PLA/ZrO_{2}$ fiber scaffolds. The in vitro biocompatibility and bioactivity of the $PLA/ZrO_{2}$ were studied using human fetal osteoblast cells. Our results showed that the hydrothermal technique allowed $ZrO_{2}$ nanoparticles to be obtained. SEM analysis showed that $PLA/ZrO_{2}$ composite has a fiber diameter of 395 nm, and the FITR spectra confirmed that the scaffolds’ chemical characteristics are not affected by the synthesized technique. In vitro studies demonstrated that $PLA/ZrO_{2}$ scaffolds increased cell adhesion, cellular proliferation, and biomineralization of osteoblasts. In conclusion, the $PLA/ZrO_{2}$ scaffolds are bioactive, improve osteoblasts behavior, and can be used in tissue bone engineering applications.
Starting Page	7597
e-ISSN	14203049
DOI	10.3390/molecules26247597
Journal	Molecules
Issue Number	24
Volume Number	26
Language	English
Publisher	MDPI
Publisher Date	2021-12-15
Access Restriction	Open
Subject Keyword	Molecules Composite Scaffold Guide Tissue Engineering Polylactic Acid (pla) Nanofibers Zirconium Ceramic Biocompatibility
Content Type	Text
Resource Type	Article

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