NDLI: Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Content Provider	MDPI
Author	Gupta, Bharti Mishra, Varsha Gharat, Sankalp Momin, Munira Omri, Abdelwahab
Copyright Year	2021
Description	One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.
Starting Page	1201
e-ISSN	14248247
DOI	10.3390/ph14111201
Journal	Pharmaceuticals
Issue Number	11
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2021-11-22
Access Restriction	Open
Subject Keyword	Pharmaceuticals Pharmacology and Pharmacy Ocular Drug Delivery System Hydroxypropyl Methylcellulose Carboxymethyl Cellulose Ethylcellulose Methylcellulose Hydroxyethyl Cellulose Solubility Sustained Release Bioavailability
Content Type	Text
Resource Type	Article

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