NDLI: Stimuli-Responsive Aliphatic Polycarbonate Nanocarriers for Tumor-Targeted Drug Delivery

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Stimuli-Responsive Aliphatic Polycarbonate Nanocarriers for Tumor-Targeted Drug Delivery

Content Provider	MDPI
Author	Adrian, Domiński Gabriela, Pastuch-Gawołek Konieczny, Tomasz Duale, Khadar Krawczyk, Monika Kurcok, Piotr
Copyright Year	2020
Description	Nanoparticles based on amphiphilic copolymers with tunable physicochemical properties can be used to encapsulate delicate pharmaceutics while at the same time improving their solubility, stability, pharmacokinetic properties, reducing immune surveillance, or achieving tumor-targeting ability. Those nanocarriers based on biodegradable aliphatic polycarbonates are a particularly promising platform for drug delivery due to flexibility in the design and synthesis of appropriate monomers and copolymers. Current studies in this field focus on the design and the synthesis of new effective carriers of hydrophobic drugs and their release in a controlled manner by exogenous or endogenous factors in tumor-specific regions. Reactive groups present in aliphatic carbonate copolymers, undergo a reaction under the action of a stimulus: e.g., acidic hydrolysis, oxidation, reduction, etc. leading to changes in the morphology of nanoparticles. This allows the release of the drug in a highly controlled manner and induces a desired therapeutic outcome without damaging healthy tissues. The presented review summarizes the current advances in chemistry and methods for designing stimuli-responsive nanocarriers based on aliphatic polycarbonates for controlled drug delivery.
Starting Page	2890
e-ISSN	20734360
DOI	10.3390/polym12122890
Journal	Polymers
Issue Number	12
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2020-12-02
Access Restriction	Open
Subject Keyword	Polymers Medicinal Chemistry Pharmacology and Pharmacy Aliphatic Polycarbonates Nanocarriers Stimuli-responsive Drug Delivery Systems
Content Type	Text
Resource Type	Article

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