Loading...
Please wait, while we are loading the content...
Similar Documents
Does Drug-Resistant Extrapulmonary Tuberculosis Hinder TB Elimination Plans? A Case from Delhi, India
| Content Provider | MDPI |
|---|---|
| Author | Lohiya, Sheelu Tripathy, Jaya Prasad Sagili, Karuna Khanna, Vishal Kumar, Ravinder Ojha, Arun Bhatnagar, Anuj Khanna, Ashwani |
| Copyright Year | 2020 |
| Description | Extrapulmonary drug-resistant tuberculosis (DR-EPTB) poses a formidable diagnostic and therapeutic challenge.Besides associated with high morbidity, it is a major financial burden for the patient and the health system. In spite of this, it has often been neglected as it does not “pose” a visible public health threat. We study clinical profiles, treatment outcomes, and factors associated with unfavourable outcomes among DR-EPTB patients under programmatic settings in New Delhi, India, and evaluate how this could impact TB elimination. A retrospective analysis of all DR-EPTB patients registered at three nodal DR-TB centres in Delhi in 2016 was carried out. Of the 1261 DR-TB patients registered, 203 (16%) were DR-EPTB, with lymph nodes (118, 58%) being the most common site, followed by bone (69, 34%). Nearly 29% (n = 58) experienced adverse drug reactions with severe vomiting (26, 13 %), joint pain (21, 10%) and behavioral disorder (15, 7%). History of previous TB treatment was observed in a majority of the cases (87.7%). Nearly one-third of DR-EPTB cases (33%) had unfavourable treatment outcomes, with loss-to-follow-up (n = 40, 58%) or death (n = 14, 20%) being the most common unfavourable outcomes. In the adjusted analysis, weight band 31–50 kilograms (aRR = 1.8, 1.2–3.4) and h/o previous TB (aRR = 2.1, 1.1–4.8) were mainly associated with unfavourable outcomes. TB elimination efforts need to focus on all forms of TB, including DR-EPTB, leaving no one behind, in order to realise the dream of ending TB. |
| Starting Page | 109 |
| e-ISSN | 24146366 |
| DOI | 10.3390/tropicalmed5030109 |
| Journal | Tropical medicine and infectious disease |
| Issue Number | 3 |
| Volume Number | 5 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-07-01 |
| Access Restriction | Open |
| Subject Keyword | Tropical medicine and infectious disease Tropical Medicine and Infectious Disease Tropical Medicine Adverse Drug Reactions Unfavourable Outcome Lymph Node Tb Bone Tb Tb Elimination Extrapulmonary Tuberculosis |
| Content Type | Text |
| Resource Type | Article |
