NDLI: Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers

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Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers

Content Provider	MDPI
Author	Helena, Tomás Wang, Zhe Zhao, Yili Shen, Mingwu Zhou, Benqing Shi, Xiangyang
Copyright Year	2022
Description	Currently, cancer chemotherapeutic drugs still have the defects of high toxicity and low bioavailability, so it is critical to design novel drug release systems for cancer chemotherapy. Here, we report a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antitumor therapy applications. In this work, rod-like attapulgite (ATT) was utilized to load a model anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT/DOX/PLGA composite nanofibers were characterized through various techniques. It is feasible to load DOX onto ATT surfaces, and the ATT/DOX/PLGA nanofibers show a smooth and uniform morphology with improved mechanical durability. Under neutral and acidic pH conditions, the loaded DOX was released from ATT/DOX/PLGA nanofibers in a sustained manner. In addition, the released DOX from the nanofibers could significantly inhibit the growth of tumor cells. Owing to the significantly reduced burst release profile and increased mechanical durability of the ATT/DOX/PLGA nanofibers, the designed organic–inorganic hybrid nanofibers may hold great promise as a nanoplatform to encapsulate different drugs for enhanced local tumor therapy applications.
Starting Page	55
e-ISSN	20794983
DOI	10.3390/jfb13020055
Journal	Journal of Functional Biomaterials
Issue Number	2
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2022-05-10
Access Restriction	Open
Subject Keyword	Journal of Functional Biomaterials Biomaterials Nanofibers Attapulgite Drug Release Poly(lactic-co-glycolic Acid) Antitumor Therapy
Content Type	Text
Resource Type	Article

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