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Causes of Exocrine Pancreatic Insufficiency Other Than Chronic Pancreatitis
| Content Provider | MDPI |
|---|---|
| Author | Lum, ír Kunovský Petr, Dítě Petr, Jabandžiev Karolina, Poredská Jitka, Vaculová Dana, Sochorová Pavel, Janeček Pavla, Tesaříková Eid, Michal Blaho, Martin Trna, Jan Hlavsa, Jan Kala, Zdeněk |
| Copyright Year | 2021 |
| Description | Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and malnutrition, results from primary pancreatic disease or is secondary to impaired exocrine pancreatic function. Although chronic pancreatitis is the most common cause of EPI, several additional causes exist. These include pancreatic tumors, pancreatic resection procedures, and cystic fibrosis. Other diseases and conditions, such as diabetes mellitus, celiac disease, inflammatory bowel disease, and advanced patient age, have also been shown to be associated with EPI, but the exact etiology of EPI has not been clearly elucidated in these cases. The causes of EPI can be divided into loss of pancreatic parenchyma, inhibition or inactivation of pancreatic secretion, and postcibal pancreatic asynchrony. Pancreatic enzyme replacement therapy (PERT) is indicated for the conditions described above presenting with clinically clear steatorrhea, weight loss, or symptoms related to maldigestion and malabsorption. This review summarizes the current literature concerning those etiologies of EPI less common than chronic pancreatitis, the pathophysiology of the mechanisms of EPI associated with each diagnosis, and treatment recommendations. |
| Starting Page | 5779 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm10245779 |
| Journal | Journal of clinical medicine |
| Issue Number | 24 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-10 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Gastroenterology and Hepatology Exocrine Pancreatic Insufficiency Pancreatic Enzyme Replacement Therapy Pancreatic Cancer Cystic Fibrosis Pancreatic Resection Surgery Diabetes Celiac Disease Inflammatory Bowel Disease Microbiome |
| Content Type | Text |
| Resource Type | Article |
