NDLI: Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors

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Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors

Content Provider	MDPI
Author	Shin, Hyeji Han, Yoo Byun, Youngjoo Jeon, Young Lee, Ki
Copyright Year	2021
Description	Thymic stromal lymphopoietin (TSLP) plays an important role in the pathophysiology of various allergic diseases that are mediated by T helper cell type-2 (Th2) responses, including asthma and atopic dermatitis. The primary focus of this study was the identification of potent inhibitors of the TSLP signaling pathway for potential therapeutic use. The 80% methanol extract of Machilus thunbergii bark significantly inhibited the signal transducer and activator of transcription 5 (STAT5) phosphorylation in human mast cell (HMC)-1 cells. Through activity-guided isolation, three lignans (1–3) were obtained and identified as (+)-galbelgin (1), meso-dihydroguaiaretic acid (2), and machilin A (3). Among them, two lignans (1 and 2) significantly inhibited STAT5 phosphorylation and TSLP/TSLPR interaction, as determined by ELISA. Our results indicated that lignans isolated from M. thunbergii are a promising resource for the treatment of allergic diseases.
Starting Page	4804
e-ISSN	14203049
DOI	10.3390/molecules26164804
Journal	Molecules
Issue Number	16
Volume Number	26
Language	English
Publisher	MDPI
Publisher Date	2021-08-08
Access Restriction	Open
Subject Keyword	Molecules Immunology Machilus Thunbergii Tslp Stat5 Allergic Disease Lignan
Content Type	Text
Resource Type	Article

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