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A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age
| Content Provider | MDPI |
|---|---|
| Author | Silvia, Pérez-Piñero Vicente, Ávila-Gandía Juan, Carlos Muñoz-Carrillo Francisco, Javier López-Román Arias, Jacobo A. Rubio Losada-Zafrilla, Pilar |
| Copyright Year | 2021 |
| Description | The aim of a 12-week randomized double-blind placebo-controlled study was to assess the effect of daily supplementation with a natural extract of Spinacia oleracea L. (4 × 500 mg capsules/day; total 2 g per day) combined with a moderate-intensity training program (1 h session/3 times a week) on skeletal muscle fitness in adults over 50 years of age. Muscle strength assessed by isokinetic and isometric dynamometry improved significantly in the experimental (n = 23) and the placebo (n = 22) groups, but the magnitude of improvement was higher in the experimental group, with between-group differences in almost all variables, including isokinetic at 60° $s^{−1}$ in knee extension, peak torque (p < 0.007); total work per repetition maximum (p < 0.009); isokinetic at $180°s^{−1}$ in knee extension, peak torque (p < 0.002); total work (p < 0.007); total work per repetition maximum (p < 0.005); average power (p < 0.027); isometric in knee extension, peak torque (p < 0.005); and average peak torque (p < 0.002). Similar findings were observed for muscle quality. Changes in quality of life (SF-36) were not found, except for improvements in the role physical (p < 0.023) and role emotional (p < 0.001) domains, likely as a result of the physical training sessions. A nutritional survey did not revealed changes in dietary habits. No adverse events were recorded. In subjects over 50 years of age, moderate-intensity strength training combined with daily supplementation for 12 weeks with a natural extract of Spinacia oleracea L. improved muscle-related variables and muscle quality. Maintaining muscle health is a key component of healthy aging. |
| Starting Page | 4373 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu13124373 |
| Journal | Nutrients |
| Issue Number | 12 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-06 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Integrative and Complementary Medicine Natural Spinach Extract Healthy Aging Muscle Health Randomized Trial Strength Training |
| Content Type | Text |
| Resource Type | Article |