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miRNA-Based Therapeutics in the Era of Immune-Checkpoint Inhibitors
| Content Provider | MDPI |
|---|---|
| Author | Huemer, Florian Leisch, Michael Geisberger, Roland Zaborsky, Nadja Greil, Richard |
| Copyright Year | 2021 |
| Description | MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to complementary target regions on gene transcripts. Thus, miRNAs fine-tune gene expression profiles in a cell-type-specific manner and thereby regulate important cellular functions, such as cell growth, proliferation and cell death. MiRNAs are frequently dysregulated in cancer cells by several mechanisms, which significantly affect the course of the disease. In this review, we summarize the current knowledge on how dysregulated miRNAs contribute to cancer and how miRNAs can be exploited as predictive factors and therapeutic targets, particularly in regard to immune-checkpoint inhibitor therapies. |
| Starting Page | 89 |
| e-ISSN | 14248247 |
| DOI | 10.3390/ph14020089 |
| Journal | Pharmaceuticals |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-26 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceuticals Oncology Mirna Microrna Immune-checkpoint Inhibitor Immune-checkpoint Blockade Predictive Ipilimumab Nivolumab Anti-pd-1 Anti-pd-l1 Anti-ctla-4 |
| Content Type | Text |
| Resource Type | Article |
