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Continuous Crystallization Using Ultrasound Assisted Nucleation, Cubic Cooling Profiles and Oscillatory Flow
| Content Provider | MDPI |
|---|---|
| Author | Vancleef, Arne Beuckeleer, Ward De Gerven, Tom Van Thomassen, Leen C. J. Braeken, Leen |
| Copyright Year | 2021 |
| Description | Continuous tubular crystallizers have the potential to reduce manufacturing costs and increase product quality. However, designing tubular crystallizers is a complex and challenging task as crystallization is a complex, multiphase process with a propensity for fouling and clogging. While several designs have been proposed to overcome these issues, these designs are either unproven or poorly scalable and complex. In this work a continuous crystallizer is designed and evaluated to mitigate these issues. The tubular crystallizer combines a novel method to obtain a cubic cooling profile to control the supersaturation, ultrasound to induce nucleation and oscillatory flow to improve mixing and minimize fouling and sedimentation. The results show that the crystallizer was able to operate for more than 4 h without clogging, with high yields and a narrow particle size distribution. The design proposed here is therefore considered a viable approach for continuous crystallizers. |
| Starting Page | 2268 |
| e-ISSN | 22279717 |
| DOI | 10.3390/pr9122268 |
| Journal | Processes |
| Issue Number | 12 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-17 |
| Access Restriction | Open |
| Subject Keyword | Processes Manufacturing Engineering Continuous Crystallization Tubular Crystallizer Oscillatory Baffleless Coil Reactors Pulsation Oscillatory Flow Cubic Cooling Profile Ultrasound Assisted Nucleation Fouling |
| Content Type | Text |
| Resource Type | Article |
