NDLI: Efficacy of Cannabidiol for Δ-9-Tetrahydrocannabinol-Induced Psychotic Symptoms, Schizophrenia, and Cannabis Use Disorders: A Narrative Review

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Efficacy of Cannabidiol for Δ-9-Tetrahydrocannabinol-Induced Psychotic Symptoms, Schizophrenia, and Cannabis Use Disorders: A Narrative Review

Content Provider	MDPI
Author	Giuseppe, Carrà Bartoli, Francesco Riboldi, Ilaria Bachi, Bianca Calabrese, Angela Moretti, Federico Crocamo, Cristina
Copyright Year	2021
Description	Although cannabis’ major psychoactive component, Δ-9-tetrahydrocannabinol (THC), has been linked to both earlier onset and poorer outcomes of psychotic disorders, Cannabidiol (CBD) seems to have different pharmacological mechanisms and potential therapeutic properties. However, no clinical study has investigated CBD for the treatment of co-occurring psychotic and cannabis use disorders so far, even though its utility seems grounded in a plausible biological basis. The aim of this work is thus to provide an overview of available clinical studies evaluating the efficacy of CBD for psychotic symptoms induced by THC, schizophrenia, and cannabis use disorders. After searching for relevant studies in PubMed, Cochrane Library, and ClinicalTrials.gov, we included 10 clinical studies. Available evidence suggests that CBD may attenuate both psychotic-like symptoms induced by THC in healthy volunteers and positive symptoms in individuals with schizophrenia. In addition, preliminary data on the efficacy of CBD for cannabis use disorders show mixed findings. Evidence from ongoing clinical studies will provide insight into the possible role of CBD for treating psychotic and cannabis use disorders.
Starting Page	1303
e-ISSN	20770383
DOI	10.3390/jcm10061303
Journal	Journal of clinical medicine
Issue Number	6
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-03-22
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Psychiatry and Mental Health Cannabidiol Δ-9-tetrahydrocannabinol Schizophrenia Psychotic Disorders Cannabis Use Disorder Dual Diagnosis
Content Type	Text
Resource Type	Article

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