NDLI: Emerging Polymer Materials in Trackable Endovascular Embolization and Cell Delivery: From Hype to Hope

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Emerging Polymer Materials in Trackable Endovascular Embolization and Cell Delivery: From Hype to Hope

Content Provider	MDPI
Author	Rana, Mohosin Melancon, Marites P.
Copyright Year	2022
Description	Minimally invasive endovascular embolization is a widely used clinical technique used for the occlusion of blood vessels to treat various diseases. Different occlusive agents ranging from gelatin foam to synthetic polymers such as poly(vinyl alcohol) (PVA) have been commercially used for embolization. However, these agents have some drawbacks, such as undesired toxicity and unintended and uncontrolled occlusion. To overcome these issues, several polymer-based embolic systems are under investigation including biocompatible and biodegradable microspheres, gelling liquid embolic with controlled occlusive features, and trackable microspheres with enhanced safety profiles. This review aims to summarize recent advances in current and emerging polymeric materials as embolization agents with varying material architectures. Furthermore, this review also explores the potential of combining injectable embolic agents and cell therapy to achieve more effective embolization with the promise of outstanding results in treating various devastating diseases. Finally, limitations and challenges in developing next-generation multifunctional embolic agents are discussed to promote advancement in this emerging field.
Starting Page	77
e-ISSN	23137673
DOI	10.3390/biomimetics7020077
Journal	Biomimetics
Issue Number	2
Volume Number	7
Language	English
Publisher	MDPI
Publisher Date	2022-06-10
Access Restriction	Open
Subject Keyword	Biomimetics Polymers Embolic Agents Hepatocellular Carcinoma Uterine Fibroids Arteriovenous Malformations Embolization
Content Type	Text
Resource Type	Article

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