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Anticoagulation for Splanchnic Vein Thrombosis in Myeloproliferative Neoplasms: The Drug and the Duration
| Content Provider | MDPI |
|---|---|
| Author | Sedhom, Wafik Stein, Brady |
| Copyright Year | 2021 |
| Description | Myeloproliferative neoplasms are a common cause of splanchnic vein thrombosis, which causes significant morbidity and mortality. Indefinite anticoagulation is the mainstay of therapy, and vitamin K antagonists (VKAs) are routinely used since hematologists have the most experience with this drug class. The role of direct oral anticoagulants (DOACs) is promising, but still undergoing evaluation. Cytoreduction with hydroxyurea or pegylated interferon is often used when cytosis is present, but their roles are yet to be defined when the complete blood count is normal. Janus kinase (JAK) inhibition may have a complementary role in reducing splenomegaly and portal hypertension. |
| Ending Page | 263 |
| Page Count | 9 |
| Starting Page | 255 |
| e-ISSN | 26736357 |
| DOI | 10.3390/hemato2020015 |
| Journal | Hemato |
| Issue Number | 2 |
| Volume Number | 2 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-05-12 |
| Access Restriction | Open |
| Subject Keyword | Hemato Splanchnic Vein Thrombosis Myeloproliferative Neoplasms Jak2 V617f Mutation Anticoagulation Polycythemia Vera |
| Content Type | Text |
| Resource Type | Article |
