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microRNAs and Inflammatory Immune Response in SARS-CoV-2 Infection: A Narrative Review
| Content Provider | MDPI |
|---|---|
| Author | Maranini, Beatrice Ciancio, Giovanni Ferracin, Manuela Cultrera, Rosario Negrini, Massimo Sabbioni, Silvia Govoni, Marcello |
| Copyright Year | 2022 |
| Description | The current SARS-CoV-2 pandemic has emerged as an international challenge with strong medical and socioeconomic impact. The spectrum of clinical manifestations of SARS-CoV-2 is wide, covering asymptomatic or mild cases up to severe and life-threatening complications. Critical courses of SARS-CoV-2 infection are thought to be driven by the so-called “cytokine storm”, derived from an excessive immune response that induces the release of proinflammatory cytokines and chemokines. In recent years, non-coding RNAs (ncRNAs) emerged as potential diagnostic and therapeutic biomarkers in both inflammatory and infectious diseases. Therefore, the identification of SARS-CoV-2 miRNAs and host miRNAs is an important research topic, investigating the host–virus crosstalk in COVID-19 infection, trying to answer the pressing question of whether miRNA-based therapeutics can be employed to tackle SARS-CoV-2 complications. In this review, we aimed to directly address ncRNA role in SARS-CoV-2-immune system crosstalk upon COVID-19 infection, particularly focusing on inflammatory pathways and cytokine storm syndromes. |
| Starting Page | 288 |
| e-ISSN | 20751729 |
| DOI | 10.3390/life12020288 |
| Journal | Life |
| Issue Number | 2 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-02-15 |
| Access Restriction | Open |
| Subject Keyword | Life Immunology Ncrnas Mirnas Lncrnas Covid-19 Sars-cov-2 Inflammatory Response Immune Response Cytokine Storm |
| Content Type | Text |
| Resource Type | Article |
