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Subsequent Malignant Neoplasms in Retinoblastoma Survivors
| Content Provider | MDPI |
|---|---|
| Author | Fabius, Armida Wijsard, Milo Van Hoefen van Leeuwen, Flora Moll, Annette |
| Copyright Year | 2021 |
| Description | Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed. |
| Starting Page | 1200 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13061200 |
| Journal | Cancers |
| Issue Number | 6 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-10 |
| Access Restriction | Open |
| Subject Keyword | Cancers Ophthalmology Retinoblastoma Subsequent Malignant Neoplasms Second Primary Malignancies Trilateral Rb Heritable Rb Long-term Surveillance |
| Content Type | Text |
| Resource Type | Article |
