NDLI: Histological Scores in Patients with Inflammatory Bowel Diseases: The State of the Art

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Histological Scores in Patients with Inflammatory Bowel Diseases: The State of the Art

Content Provider	MDPI
Author	D’amico, Ferdinando Vespa, Edoardo Sollai, Mauro Allocca, Mariangela Furfaro, Federica Zilli, Alessandra Buono, Arianna Dal Gabbiadini, Roberto Danese, Silvio Fiorino, Gionata
Copyright Year	2022
Description	The histological assessment has been advocated as a detailed and accurate measure of disease activity in inflammatory bowel diseases (IBD). In ulcerative colitis (UC), histological activity has been demonstrated to be associated with higher rates of relapse, prolonged corticosteroid use and long-term complications, even when endoscopic remission is achieved. Therefore, histological healing may represent a potential treatment target. Several histological scores have been developed and are available today. The Robarts histopathology index (RHI) and the Nancy index (NI) are the only two recommended by the European Crohn’s and Colitis Organization (ECCO) for use in patients with UC. Conversely, in Crohn’s disease (CD), the discontinuous nature of lesions has limited standardized histological assessment. Most of the available histological scoring systems in CD are complex and not validated. The aim of this review is to comprehensively summarize the latest evidence regarding histological scoring systems in IBD. We guide the reader through understanding the importance of an accurate microscopic evaluation using validated scoring systems, highlighting the strengths and pitfalls of each score. The priorities of future research needs are also addressed.
Starting Page	939
e-ISSN	20770383
DOI	10.3390/jcm11040939
Journal	Journal of clinical medicine
Issue Number	4
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-02-11
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Gastroenterology and Hepatology Histology Score Ibd Ulcerative Colitis Crohn's Disease Histological Remission
Content Type	Text
Resource Type	Article

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