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Novel Synergistic Anti-Enteroviral Drug Combinations
Content Provider | MDPI |
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Author | Magnar, Bjørås Ianevski, Aleksandr Zusinaite, Eva Tenson, Tanel Oksenych, Valentyn Wang, Wei Afset, Jan Egil Kainov, Denis E. |
Copyright Year | 2022 |
Description | Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: We have tested our library of broad-spectrum antiviral agents (BSAs) against echovirus 1 (EV1) in human adenocarcinoma alveolar basal epithelial A549 cells. We also tested combinations of the most active compounds against EV1 in A549 and human immortalized retinal pigment epithelium RPE cells. Results: We confirmed anti-enteroviral activities of pleconaril, rupintrivir, cycloheximide, vemurafenib, remdesivir, emetine, and anisomycin and identified novel synergistic rupintrivir–vemurafenib, vemurafenib–pleconaril and rupintrivir–pleconaril combinations against EV1 infection. Conclusions: Because rupintrivir, vemurafenib, and pleconaril require lower concentrations to inhibit enterovirus replication in vitro when combined, their cocktails may have fewer side effects in vivo and, therefore, should be further explored in preclinical and clinical trials against EV1 and other enterovirus infections. |
Starting Page | 1866 |
e-ISSN | 19994915 |
DOI | 10.3390/v14091866 |
Journal | Viruses |
Issue Number | 9 |
Volume Number | 14 |
Language | English |
Publisher | MDPI |
Publisher Date | 2022-08-25 |
Access Restriction | Open |
Subject Keyword | Viruses Infectious Diseases Echovirus Enterovirus Broad-spectrum Antiviral Agent Antiviral Drug Combination Antiviral Strategy |
Content Type | Text |
Resource Type | Article |