NDLI: Multi-Residue Determination of 244 Chemical Contaminants in Chicken Eggs by Liquid Chromatography-Tandem Mass Spectrometry after Effective Lipid Clean-Up

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Multi-Residue Determination of 244 Chemical Contaminants in Chicken Eggs by Liquid Chromatography-Tandem Mass Spectrometry after Effective Lipid Clean-Up

Content Provider	MDPI
Author	Zhang, Lin Jia, Qi Liao, Guangqin Qian, Yongzhong Qiu, Jing
Copyright Year	2022
Description	In this study, we aimed to establish a multi-residue analytical method for the simultaneous detection of chemical contaminants in eggs. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we developed an analytical method that can separate 244 compounds (including β-agonists (25), imidazole and benzimidazoles (31), sulfonamides (22), antihistamines (10), β-lactam (5), insecticides (7), quinolones (24), non-steroidal anti-inflammatory drugs (13), and steroidal hormones (38)) within 30 min. A new enhanced matrix removal-lipid (EMR-Lipid) material was used as a purified sorbent in the QuEChERS clean-up method. Excellent linearity (r > 0.9905) was achieved. Additionally, recoveries ranged between 51.33% and 118.28%, with repeatability $(RSD_{r}$) and reproducibility $(RSD_{wR}$) in the range of 1.01–14.22% and 1.08–14.96%, respectively. In all of the compounds, low limits of quantification (LOQs) ≤ 5 μg $kg^{−1}$ were found. Meanwhile, the detection limit (CCα) and detection capability (CCβ) were 1.88–40.60 μg $kg^{−1}$ and 2.85–407.19 μg $kg^{−1}$, respectively. In conclusion, the evaluated method was shown to provide reliable screening, quantification, and identification of 244 multi-class chemicals in eggs and was successfully applied in real samples.
Starting Page	869
e-ISSN	20770472
DOI	10.3390/agriculture12060869
Journal	Agriculture
Issue Number	6
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-06-16
Access Restriction	Open
Subject Keyword	Agriculture Analytical Chemistry Eggs Multi-residue Emr-lipid Lc-ms/ms
Content Type	Text
Resource Type	Article

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