NDLI: A Review of the Clinical Implications of Cachexia, Sarcopenia, and BMI in Patients with Peritoneal Carcinomatosis Receiving Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

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A Review of the Clinical Implications of Cachexia, Sarcopenia, and BMI in Patients with Peritoneal Carcinomatosis Receiving Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Content Provider	MDPI
Author	Freudenberger, Devon C. Vudatha, Vignesh Riner, Andrea N. Herremans, Kelly M. Fernandez, Leopoldo J. Trevino, Jose G.
Copyright Year	2022
Description	Peritoneal carcinomatosis (PC) is the dissemination of cancer throughout the peritoneal cavity. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is the surgical treatment of choice in highly selected patients. The aim of this narrative review was to assess the impact of cachexia, sarcopenia, and body mass index (BMI) on patient outcomes for patients undergoing CRS and HIPEC for peritoneal carcinomatosis. A narrative review was performed and articles pertaining to cachexia, sarcopenia, BMI, peritoneal carcinomatosis, and CRS/HIPEC were reviewed and selected. In total, 3041 articles were screened and seven original studies met the inclusion criteria. In summary, obesity was found to not be a contraindication to surgery, but the impact of BMI was variable across the spectrum. Decreased skeletal muscle mass was found to be associated with poorer postoperative outcomes in three studies and with worse overall survival in two. With limited data, evaluating the impact of BMI, sarcopenia, and cachexia on patients with PC undergoing CRS and HIPEC was difficult as most studies included heterogeneous cancer patient populations; thus, postoperative outcomes and survival were inconsistent across studies. More research is needed to better understand its impact and to better generalize the results for each cancer subset treated with CRS and HIPEC across diverse patient populations.
Starting Page	2853
e-ISSN	20726694
DOI	10.3390/cancers14122853
Journal	Cancers
Issue Number	12
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-06-09
Access Restriction	Open
Subject Keyword	Cancers Anesthesiology Surgery Peritoneal Carcinomatosis Cytoreductive Surgery Hipec (hyperthermic Intraperitoneal Chemotherapy) Cachexia Sarcopenia Bmi
Content Type	Text
Resource Type	Article

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