NDLI: Distinct and Overlapping Patterns of Acute Ethanol-Induced C-Fos Activation in Two Inbred Replicate Lines of Mice Selected for Drinking to High Blood Ethanol Concentrations

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Distinct and Overlapping Patterns of Acute Ethanol-Induced C-Fos Activation in Two Inbred Replicate Lines of Mice Selected for Drinking to High Blood Ethanol Concentrations

Content Provider	MDPI
Author	Robinson, Stacey Dornellas, Ana Burnham, Nathan Houck, Christa Luhn, Kendall Bendrath, Sophie Brewton, Honoreé Thomas, Rhiannon Navarro, Montserrat Thiele, Todd
Copyright Year	2020
Description	The inbred high drinking in the dark (iHDID1 and iHDID2) strains are two replicate lines bred from the parent HS/Npt (HS) line for achieving binge levels of blood ethanol concentration (≥80 mg/dL BEC) in a four-hour period. In this work, we sought to evaluate differences in baseline and ethanol-induced c-Fos activation between the HS, iHDID1, and iHDID2 genetic lines in brain regions known to process the aversive properties of ethanol. Methods: Male and female HS, iHDID1, and iHDID2 mice underwent an IP saline 2 3 g/kg ethanol injection. Brain sections were then stained for c-Fos expression in the basolateral/central amygdala (BLA/CeA), bed nucleus of the stria terminals (BNST), A2, locus coeruleus (LC), parabrachial nucleus (PBN), lateral/medial habenula (LHb/MHb), paraventricular nucleus of the thalamus (PVT), periaqueductal gray (PAG), Edinger–Westphal nuclei (EW), and rostromedial tegmental nucleus (RMTg). Results: The iHDID1 and iHDID2 lines showed similar and distinct patterns of regional c-Fos; however, in no region did the two both significantly differ from the HS line together. Conclusions: These data lend further support to altered baseline or ethanol-induced activation in brain regions associated with processing the aversive properties of ethanol in the iHDID1 and iHDID2 genetic lines.
Starting Page	988
e-ISSN	20763425
DOI	10.3390/brainsci10120988
Journal	Brain Sciences
Issue Number	12
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2020-12-15
Access Restriction	Open
Subject Keyword	Brain Sciences Substance Abuse Hdid C-fos Mice Ethanol Alcohol Drinking in the Dark Taste Aversion
Content Type	Text
Resource Type	Article

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