NDLI: Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Patients with Liver Cirrhosis

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Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Patients with Liver Cirrhosis

Content Provider	MDPI
Author	Chen, Wen-Chi Hung, Chih-Hsin Chen, Yao-Shen Cheng, Jin-Shiung Lee, Susan Tseng, Fan-Chen Cheng, Ming-Fang Wang, Jiun-Ling
Copyright Year	2021
Description	Background: This study aimed to investigate the frequency of sequence type (ST) 131 strains and outcome of cirrhotic patients with bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing Escherichiacoli (ESBLEC) and non-extended-spectrum beta-lactamase-producing Escherichiacoli (NESBLEC). Methods: The incidence of ST 131 strains, hospital stay, and 30-day re-admission/mortality were compared between 51 ESBLEC and 51 NESBLEC bacteremic patients with cirrhosis. Results: ST 131 strains were found in 35.3% of the ESBLEC group and 0% of the NESBLEC group (p < 0.001). Mean hospital stay was 26.5 days in the ESBLEC group and 17.1 days in the NESBLEC group (p = 0.006). Thirty-day re-admission rates were 11.8% in the ESBLEC group and 5.9% in the NESBLEC group (p = 0.5). ST 131 strains were associated with 30-day re-admission (odds ratio: 4.5, 95% confidence interval: 1.1–18.9). Thirty-day mortality rate was 31.4% in the ESBLEC group and 23.5% in the NESBLEC group (p = 0.4). Conclusion: In patients with cirrhosis, the ESBLEC BSIs group had a higher frequency of ST 131 strains and longer hospital stay than the NESBLEC BSIs group with similar 30-day re-admission/mortality. ST 131 strains were associated with 30-day re-admission.
Starting Page	37
e-ISSN	20760817
DOI	10.3390/pathogens10010037
Journal	Pathogens
Issue Number	1
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-01-05
Access Restriction	Open
Subject Keyword	Pathogens Bacteremia Cirrhosis Escherichia Coli Extended-spectrum Beta-lactamase Sequence Type 131
Content Type	Text
Resource Type	Article

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