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In Situ Photopolymerization of Acrylamide Hydrogel to Coat Cellulose Acetate Nanofibers for Drug Delivery System
| Content Provider | MDPI |
|---|---|
| Author | Arifuzzaman, Attia, Mohamed Montaser, Ahmed Pitz, Megan Jlassi, Khouloud Alexander-Bryant, Angela Kelly, Stephen Alexis, Frank Whitehead, Daniel |
| Copyright Year | 2021 |
| Description | In this study we developed electrospun cellulose acetate nanofibers (CANFs) that were loaded with a model non-steroidal anti-inflammatory drug (NSAID) (ibuprofen, Ib) and coated with poly(acrylamide) (poly-AAm) hydrogel polymer using two consecutive steps: an electrospinning process followed by photopolymerization of AAm. Coated and non-coated CANF formulations were characterized by several microscopic and spectroscopic techniques to evaluate their physicochemical properties. An analysis of the kinetic release profile of Ib showed noticeable differences due to the presence or absence of the poly-AAm hydrogel polymer. Poly-AAm coating facilitated a constant release rate of drug as opposed to a more conventional burst release. The non-coated CANFs showed low cumulative drug release concentrations (ca. 35 and 83% at 5 and 10% loading, respectively). Conversely, poly-AAm coated CANFs were found to promote the release of drug (ca. 84 and 99.8% at 5 and 10% loading, respectively). Finally, the CANFs were found to be superbly cytocompatible. |
| Starting Page | 1863 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym13111863 |
| Journal | Polymers |
| Issue Number | 11 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-03 |
| Access Restriction | Open |
| Subject Keyword | Polymers Paper and Wood Electrospinning Cellulose Acetate Nanofibers Poly(acrylamide) Hydrogel Drug Delivery Kinetic Release |
| Content Type | Text |
| Resource Type | Article |
