NDLI: Liquid Chromatography Tandem Mass Spectrometry for the Simultaneous Quantification of Eleven Phytochemical Constituents in Traditional Korean Medicine, Sogunjung Decoction

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Liquid Chromatography Tandem Mass Spectrometry for the Simultaneous Quantification of Eleven Phytochemical Constituents in Traditional Korean Medicine, Sogunjung Decoction

Content Provider	MDPI
Author	Seo, Chang-Seob Shin, Hyeun-Kyoo
Copyright Year	2021
Description	The Sogunjung decoction (SGJD) is a traditional herbal formula that has been used to treat constipation and improve the constitution of infirm children in Korea. In this study, simultaneous quantification of gallic acid (1), magnoflorine (2), albiflorin (3), paeoniflorin (4), liquiritin apioside (5), liquiritin (6), liquiritigenin (7), coumarin (8), cinnamaldehyde (9), benzoylpaeoniflorin (10), and glycyrrhizin (11) was conducted using fast and sensitive liquid chromatography–tandem mass spectrometry (LC–MS) multiple-reaction monitoring to develop a quality-control protocol for the SGJD. A Waters Acquity UPLC BEH C18 column (2.1 × 100 mm, 1.7 μm) was used for the chromatographic separation of the 11 marker compounds in the SGJD using two mobile phases (5 mM ammonium acetate in distilled water containing 0.1% (v/v) formic acid, and acetonitrile). The MS parameters for a simultaneous analysis were capillary voltage (3.0 kV), source temperature (150 °C), desolvation temperature (500 °C), desolvation gas flow (700 L/h), and cone gas flow (50 L/h). The developed LC–MS method was validated by the evaluation of linearity, limits of detection, limits of quantification, recovery and precision. By using the developed and validated assay, the 11 marker components in the SGJD were detected in amounts of 0.01–51.83 mg/g.
Starting Page	153
e-ISSN	22279717
DOI	10.3390/pr9010153
Journal	Processes
Issue Number	1
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2021-01-14
Access Restriction	Open
Subject Keyword	Processes Integrative and Complementary Medicine Liquid Chromatography Tandem Mass Spectrometry Simultaneous Quantification Sogunjung Decoction
Content Type	Text
Resource Type	Article

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