NDLI: Untargeted Ultrahigh-Performance Liquid Chromatography-Hybrid Quadrupole-Orbitrap Mass Spectrometry (UHPLC-HRMS) Metabolomics Reveals Propolis Markers of Greek and Chinese Origin

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Untargeted Ultrahigh-Performance Liquid Chromatography-Hybrid Quadrupole-Orbitrap Mass Spectrometry (UHPLC-HRMS) Metabolomics Reveals Propolis Markers of Greek and Chinese Origin

Content Provider	MDPI
Author	Stavropoulou, Maria-Ioanna Termentzi, Aikaterini Kasiotis, Konstantinos Cheilari, Antigoni Stathopoulou, Konstantina Machera, Kyriaki Aligiannis, Nektarios
Copyright Year	2021
Description	Chemical composition of propolis depends on the plant source and thus on the geographic and climatic characteristics of the site of collection. The aim of this study was to investigate the chemical profile of Greek and Chinese propolis extracts from different regions and suggest similarities and differences between them. Untargeted ultrahigh-performance liquid chromatography coupled to hybrid quadrupole-Orbitrap mass spectrometry (UHPLC-HRMS) method was developed and 22 and 23 propolis samples from Greece and China, respectively, were analyzed. The experimental data led to the observation that there is considerable variability in terms of quality of the distinctive propolis samples. Partial least squares - discriminant analysis (PLS-DA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) models were constructed and allowed the identification of significant features for sample discrimination, adding relevant information for the identification of class-determining metabolites. Chinese samples overexpressed compounds that are characteristic of the poplar type propolis, whereas Greek samples overexpress the latter and the diterpenes characteristic of the Mediterranean propolis type.
Starting Page	456
e-ISSN	14203049
DOI	10.3390/molecules26020456
Journal	Molecules
Issue Number	2
Volume Number	26
Language	English
Publisher	MDPI
Publisher Date	2021-01-16
Access Restriction	Open
Subject Keyword	Molecules Biochemical Research Mediterranean Propolis Poplar Propolis Greek Propolis Chinese Propolis Uhplc-hrms Chemometrics
Content Type	Text
Resource Type	Article

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